SB-399885 (hydrochloride)

SB-399885 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 0.72 nM). It is greater than 200-fold selective for 5-HT6 receptors over a panel of receptors, ion channels, and enzymes at 10 µM. SB-399885 inhibits 5-HT-induced cAMP accumulation in HeLa cells expressing recombinant human 5-HT6 receptors (pA2 = 7.85). In vivo, SB-399885 increases the seizure threshold in a rat model of seizures induced by maximal electroshock (MES). It reduces escape latency in the Morris water maze in aged rats and reverses scopolamine-induced impairments in the novel object recognition task in adult rats when administered at a dose of 10 mg/kg. SB-399885 (10 mg/kg) decreases immobility time in the forced swim and tail suspension tests in mice. It also increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, in rats.Formal Name: N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-benzenesulfonamide, monohydrochloride. CAS Number: 402713-81-9. Molecular Formula: C18H21Cl2N3O4S . HCl. Formula Weight: 482.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=S(NC1=C(OC)C(Cl)=CC(Cl)=C1)(C2=CC=C(C(N3CCNCC3)=C2)OC)=O.Cl. InChi Code: InChI=1S/C18H21Cl2N3O4S.ClH/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2,/h3-4,9-11,21-22H,5-8H2,1-2H3,1H. InChi Key: RNKCEBCFUSXSQE-UHFFFAOYSA-N.