Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay11019-5 5 mg -

1 - 10 business days

Cay11019-10 10 mg -

1 - 10 business days

Cay11019-25 25 mg -

1 - 10 business days

Cay11019-50 50 mg -

1 - 10 business days

The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation... more
Product information "SB-366791"
The transient receptor potential vanilloid type 1 (TRPV1) receptor is a nonselective cation channel gated by noxious heat, protons, and capsaicin. TRPV1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals and plays a role in thermal and mechanical hyperalgesia. SB-366791 is a selective TRPV1 antagonist that is widely used in pain research. In cultured trigeminal ganglion neurons, SB-366791 inhibits capsaicin-evoked Ca2+ influx with an IC50 value of 0.7 µM. A 1 nmol injection of SB-366791 in mouse paw reduces capsaicin-induced nociceptive responses in a model of pain. Intrathecal pretreatment of 10 µl SB-366791 in rats suppresses tolerance to the analgesic effects of chronic morphine administration. Co-administration of morphine and SB-366791 at 0.1 mg/kg has potent analgesic effects in a mouse model of bone cancer pain.
Keywords: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
Supplier: Cayman Chemical
Supplier-Nr: 11019-5


Application: TRPV1 antagonist
MW: 287.7 D
Formula: C16H14ClNO2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 472981-92-3| Search using CAS
KEGG ID : K05222 | Search using KEGG ID

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Our products are for laboratory research use only: Not for administration to humans!
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