SB 297006

SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3, IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1delta. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).Formal Name: N-benzoyl-4-nitro-L-phenylalanine, ethyl ester. CAS Number: 58816-69-6. Molecular Formula: C18H18N2O5. Formula Weight: 342.4. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: O=C(C1=CC=CC=C1)N[C@H](C(OCC)=O)CC2=CC=C([N+]([O-])=O)C=C2. InChi Code: InChI=1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1. InChi Key: BEZXGSZPWXRHIN-INIZCTEOSA-N.