SB 218795

Description: SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1. Target: Neurokinin receptor. Smiles: C(N[C@@H](C(OC)=O)C1=CC=CC=C1)(=O)C=2C3=C(N=C(C2)C4=CC=CC=C4)C=CC=C3. References: Medhurst AD, et, al. In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br J Pharmacol. 1997 Oct,122(3):469-76.