Sanggenone C

Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities. It inhibits TNF-alpha- or IL-1beta-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs, IC50s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-kappaB activation in HSCs. Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 µM. It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis. It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.Formal Name: (5aR,10aS)-2-[(1S,5S,6R)-6-(2,4-dihydroxybenzoyl)-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-5a,10a-dihydro-1,3,8,10a-tetrahydroxy-5a-(3-methyl-2-buten-1-yl)-11H-benzofuro[3,2-b][1]benzopyran-11-one. CAS Number: 80651-76-9. Molecular Formula: C40H36O12. Formula Weight: 708.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 285, 311 nm. SMILES: O=C1[C@]2(O)[C@](C3=CC=C(O)C=C3O2)(C/C=C(C)\C)OC4=C1C(O)=C([C@]5([H])[C@H](C(C6=C(O)C=C(O)C=C6)=O)[C@](C7=CC=C(O)C=C7O)([H])CC(C)=C5)C(O)=C4. InChi Code: InChI=1S/C40H36O12/c1-18(2)10-11-39-27-9-6-22(43)16-31(27)52-40(39,50)38(49)35-32(51-39)17-30(46)34(37(35)48)26-13-19(3)12-25(23-7-4-20(41)14-28(23)44)33(26)36(47)24-8-5-21(42)15-29(24)45/h4-10,13-17,25-26,33,41-46,48,50H,11-12H2,1-3H3/t25-,26+,33-,39-,40-/m1/s1. InChi Key: XETHJOZXBVWLLM-HUKCQOFTSA-N. Origin: Plant/Cortex Mori Radicis.