Sanggenon C

Description: Sanggenon C is a flavanone Diels-Alder adduct compound isolated from the root bark of Morus alba. Sanggenon C can inhibit NF-kappaB activity, inhibit the expression of inducible nitric oxide synthase in RAW264.7 cells, and inhibit tumor necrosis factor-alpha-stimulated cell adhesion and vascular cell adhesion molecule-1 expression, Sanggenon C also has antioxidant and anti-inflammatory effects, and also has the effect of inhibiting pancreatic lipase. [1,2]. Target: Apoptosis, NF-kappaB, ERK, Phosphatase. Smiles: CC(C)=CC[C@]12Oc3cc(O)c([C@H]4C=C(C)C[C@@H]([C@H]4C(=O)c4ccc(O)cc4O)c4ccc(O)cc4O)c(O)c3C(=O)[C@@]1(O)Oc1cc(O)ccc21. References: Xiao L, et al. Sanggenon C protects against pressure overloadâ??induced cardiac hypertrophy via the calcineurin/NFAT2 pathway. Mol Med Rep. 2017 Oct,16(4):5338-5346.