Salvinorin B Mesylate

Salvinorin B mesylate (Mesyl Sal B) is a selective kappa-opioid receptor agonist that is more potent than salvinorin A (Cay-11487) in CHO cells transfected with the human kappa-opioid receptor (EC50s = 30 and 40 nM, respectively). It is a mesylated version of salvinorin B (Cay-11488) and is highly selective for kappa-opioid receptors over µ- and delta-opioid receptors. In vitro, it increases dopamine uptake via the dopamine transporter (DAT) in an ERK1/2-dependent manner but does not alter expression of DAT on the cell membrane. In rats, it increases the pain threshold and blocks reinstatement of cocaine drug-seeking.Formal Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-9-[(methylsulfonyl)oxy]-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid, methyl ester. CAS Number: 862073-79-8. Synonyms: Divinorin B Mesylate, Mesyl Sal B, Sal B Mesylate. Molecular Formula: C22H28O9S. Formula Weight: 468.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml, Ethanol: slightly soluble. lambdamax: 205 nm. SMILES: [H][C@@]12CC[C@@]([C@@]3([H])[C@@]1(C)C[C@@H](C4=COC=C4)OC2=O)(C)[C@H](C(OC)=O)C[C@H](OS(C)(=O)=O)C3=O. InChi Code: InChI=1S/C22H28O9S/c1-21-7-5-13-20(25)30-16(12-6-8-29-11-12)10-22(13,2)18(21)17(23)15(31-32(4,26)27)9-14(21)19(24)28-3/h6,8,11,13-16,18H,5,7,9-10H2,1-4H3/t13-,14-,15-,16-,18-,21-,22-/m0/s1. InChi Key: JPQCLBRBPPZECE-VOVNARLJSA-N.