(S,R,S)-AHPC-Me

Item number	Size	Delivery time	Price
TGM-T7752-10mg	10 mg	7 - 10 business days*	40.00€
TGM-T7752-25mg	25 mg	7 - 10 business days*	72.00€
TGM-T7752-50mg	50 mg	7 - 10 business days*	108.00€
TGM-T7752-100mg	100 mg	7 - 10 business days*	161.00€
TGM-T7752-200mg	200 mg	7 - 10 business days*	242.00€
TGM-T7752-500mg	500 mg	7 - 10 business days*	395.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Description: (S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL... more

Close menu

Product information "(S,R,S)-AHPC-Me"

Description: (S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is an (S,R,S)-AHPC-based VHL ligand used to recruit the von Hippel-Lindau (VHL) protein. It is utilized in the synthesis of ARV-771, a VHL E3 ligase-based BET PROTAC degrader that effectively degrades BET proteins in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM. Target: Ligand for E3 Ligase. Smiles: C([C@H](C(C)(C)C)N)(=O)N1[C@H](C(N[C@@H](C)C2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@@H](O)C1. References: Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28,113(26):7124-9.

Keywords:	E3 ligase Ligand 1A, VHL ligand 2
Supplier:	TargetMol
Supplier-Nr:	T7752

Properties

Application:	Protac(R) reagent
MW:	444.59 D
Formula:	C23H32N4O3S

Database Information

CAS :	1948273-02-6\| Matching products
KEGG ID :	K03871 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

Information about the product reference will follow. more

Close menu

You will get a certificate here

Go back

Read, write and discuss reviews... more

Close menu

Customer review for "(S,R,S)-AHPC-Me"

Write a review