(S)-Laudanosine

Description: (S)-Laudanosine is the corresponding isomer of Laudanosine, which crosses the blood-brain barrier, causing euphoria and seizures, with potential systemic toxicity and analgesic effects. In the cardiovascular system, high plasma concentrations can lead to hypotension and bradycardia.Laudanosine interacts with gamma-aminobutyric acid, opioid, and nicotinic acetylcholine receptors, and inhibits the low-affinity GABA receptor, as well as competitively binds to the opioid receptor Mu-1 receptor. Target: Others. Smiles: C([C@H]1C=2C(=CC(OC)=C(OC)C2)CCN1C)C3=CC(OC)=C(OC)C=C3. References: Chapple DJ, et al. Cardiovascular and neurological effects of laudanosine. Studies in mice and rats, and in conscious and anaesthetized dogs. Br J Anaesth. 1987 Feb,59(2):218-25.