(S)-BAY-598

(S)-BAY-598 is a selective inhibitor of SMYD2. It inhibits the methylation of p53 at lysine 370 in vitro and in whole cells with IC50 values of 27 nM and Structural Genomics Consortium (SGC). The negative control, BAY-369, for (S)-BAY-598 is also available exclusively through the SGC. You can submit a request to receive the negative control here.Formal Name: (S,Z)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide. CAS Number: 1906919-67-2. Molecular Formula: C22H20Cl2F2N6O3. Formula Weight: 525.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 239, 324 nm. SMILES: ClC1=C(Cl)C=CC(C2=NN(/C(NC3=CC=CC(OC(F)F)=C3)=N\C#N)C[C@@H]2N(C(CO)=O)CC)=C1. InChi Code: InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13)22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H,28,29)/t18-/m0/s1. InChi Key: OTTJIRVZJJGFTK-SFHVURJKSA-N.