(S)-(+)-5-Oxo-2-tetrahydrofurancarboxylic acid

(S)-(+)-5-Oxo-2-tetrahydrofurancarboxylic acid is a chiral lactone compound widely utilized in organic synthesis and medicinal chemistry. It serves as a versatile ligand for forming water-soluble silver(I) complexes, which exhibit notable antibacterial and antifungal properties. Additionally, this compound acts as a chiral resolving agent in the multi-step synthesis of phosphatidylinositol 3,5-bisphosphate, a crucial lipid involved in cellular signaling. Furthermore, it is employed in the preparation of municatacin analogs, which demonstrate cytotoxic activity against tumor cells, highlighting its potential in cancer research. Due to its unique structural features, (S)-(+)-5-Oxo-2-tetrahydrofurancarboxylic acid is an essential intermediate in the development of biologically active compounds and chiral catalysts. This compound has also been described as a reversible proline dehydrogenase (PRODH) inhibitor.