(S)-(-)-5-Fluorowillardiine (hydrochloride)

(S)-(-)-5-Fluorowillardiine is an agonist of the ionotropic glutamate receptors GluA1 and GluA2. It selectively activates GluA1 and GluA2 over GluA3 and GluA4 in voltage-clamp assays using X. laevis oocytes expressing the flip isoforms of the rat receptors (EC50s = 0.382, 0.463, 20.9, and 11.9 µM, respectively). (S)-(-)-5-Fluorowillardiine induces evoked population spikes in isolated rat CA1 hippocampal slices in an in vitro model of seizure-like activity (EC50 = 0.03-0.08 µM). It induces cytotoxicity in primary mouse cortical neurons in a concentration-dependent manner, an effect that can be reversed by the GluA5 antagonist LY293558 or GluK2 antagonist NS-102.Formal Name: alpha-amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, monohydrochloride. CAS Number: 1321546-70-6. Molecular Formula: C7H8FN3O4 . HCl. Formula Weight: 253.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: Soluble. SMILES: OC([C@@H](N)CN1C(NC(C(F)=C1)=O)=O)=O.Cl. InChi Code: InChI=1S/C7H8FN3O4.ClH/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12,/h1,4H,2,9H2,(H,13,14)(H,10,12,15),1H/t4-,/m0./s1. InChi Key: TXWOAFHJFQTAEW-WCCKRBBISA-N.