Rutin (hydrate)

Rutin is a flavonoid glycoside that has been found in buckwheat and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) and ABTS (Cay-27317) radicals when used at a concentration of 163.79 µM, as well as inhibits iron autoxidation, in cell-free assays. Dietary administration of rutin (0.2% w/v) reduces tumor growth and the number of lung metastases in a B16/F10 murine melanoma model. Rutin (50 and 100 mg/kg) decreases intestinal acidity, increases intestinal activity of superoxide dismutase (SOD) and catalase, and reduces intestinal levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS) formation in a rat model of intestinal toxicity induced by methotrexate (Cay-13960). It also increases the time spent exploring the novel object in the novel object recognition (NOR) test and increases recognition and discriminative indices in a rat model of short-term episodic memory deficits induced by scopolamine (Cay-14108).Formal Name: 3-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one, trihydrate. CAS Number: 250249-75-3. Synonyms: Quercetin-3-O-rutinoside, Rutoside, Sophorin. Molecular Formula: C27H30O16 . 3H2O. Formula Weight: 664.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 25 mg/ml. lambdamax: 257, 359 nm. SMILES: O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(O)=C3)=C1O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)O4.O.O.O. InChi Code: InChI=1S/C27H30O16.3H2O/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9,,,/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3,3*1H2/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-,. InChi Key: NLLBWFFSGHKUSY-JPRRWYCFSA-N. Origin: Plant/Styphnolobium japonicum.