RSC-133

RSC-133 is an indole compound that promotes the reprogramming of human somatic cells to pluripotent stem cells. Specifically, when used at 10 µM with four standard reprogramming factors, it increases the number of human foreskin fibroblasts that express the stem cell marker alkaline phosphatase. RSC-133 induces pluripotency by both down-regulating inducers of cellular senescence and inhibiting DNA methyltransferase and histone deacetylase activities.Formal Name: 3-[[(2E)-3-(1H-indol-3-yl)-1-oxo-2-propen-1-yl]amino]-benzamide. CAS Number: 1418131-46-0. Molecular Formula: C18H15N3O2. Formula Weight: 305.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml. lambdamax: 224, 277, 340, 351 nm. SMILES: O=C(NC1=CC=CC(C(N)=O)=C1)/C=C/C2=CNC3=C2C=CC=C3. InChi Code: InChI=1S/C18H15N3O2/c19-18(23)12-4-3-5-14(10-12)21-17(22)9-8-13-11-20-16-7-2-1-6-15(13)16/h1-11,20H,(H2,19,23)(H,21,22)/b9-8+. InChi Key: HYUDSQGICKAEGE-CMDGGOBGSA-N.