Rosarin

Rosarin is a glycoside that has been found in R. rosea and has anti-inflammatory and immune regulatory activities. It prevents LPS-induced increases in induced nitric oxide synthase (iNOS), TNF-alpha, IL-1beta, and IL-6 levels in BV-2 microglia when used at concentrations of 10 and 50 µg/ml. Rosarin reduces LPS-induced nitric oxide (NO) production in BV-2 microglia. It inhibits the growth of Jurkat T cells induced by concanavalin A (Cay-14951) or anti-CD3 and anti-CD28 antibodies (IC50s = 60 and 68 µM, respectively) and increases TRAIL levels in isolated mouse splenic T cells when used at concentrations of 0.5, 5, and 50 µM.Formal Name: (2E)-3-phenyl-2-propen-1-yl 6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranoside. CAS Number: 84954-93-8. Molecular Formula: C20H28O10. Formula Weight: 428.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 251 nm. SMILES: O[C@H]([C@H]([C@@H]1O)O)[C@H](OC/C=C/C2=CC=CC=C2)O[C@@H]1CO[C@H]3[C@H](O)[C@@H](O)[C@H](CO)O3. InChi Code: InChI=1S/C20H28O10/c21-9-12-14(22)17(25)20(29-12)28-10-13-15(23)16(24)18(26)19(30-13)27-8-4-7-11-5-2-1-3-6-11/h1-7,12-26H,8-10H2/b7-4+/t12-,13+,14-,15+,16-,17+,18+,19+,20+/m0/s1. InChi Key: IEBFEMIXXHIISM-YZOUKVLTSA-N. Origin: Plant/Rhodiola rosea.