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Description: Ro 31-8220 is a potent inhibitor of PKC with IC50 values of 5, 24, 14, 27, 24, and 23 nM for PKCalpha, PKCbetaI, PKCbetaII, PKCgamma, PKCepsilon, and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3beta with IC50 values of 3, 8, 15, and 38 nM, respectively, without affecting MKK3, MKK4, MKK6, and MKK7. Target: Others. Smiles: O=C1C(C=2C=3C(N(CCCSC(=N)N)C2)=CC=CC3)=C(C(=O)N1)C=4C=5C(N(C)C4)=CC=CC5
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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