Ro 04-6790 (hydrochloride hydrate)

Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 44.7 nM). It is selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75). In vivo, Ro 04-6790 (10 and 30 mg/kg) induces stretching and yawning behavior in rats. It reverses scopolamine-induced decreases in novel object discrimination in rats. Ro 04-6790 (3, 10, and 30 mg/kg) also attenuates cue-induced cocaine-seeking behavior in rats.Formal Name: 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenesulfonamide, dihydrochloride hydrate. Molecular Formula: C12H16N6O2S . 2HCl [XH2O]. Formula Weight: 381.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 15 mg/ml, Water: 5 mg/ml. SMILES: O=S(NC1=NC(NC)=NC(NC)=C1)(C2=CC=C(C=C2)N)=O.Cl.Cl.O. InChi Code: InChI=1S/C12H16N6O2S.2ClH.H2O/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9,,,/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18),2*1H,1H2. InChi Key: NAXNKMHJJJLURY-UHFFFAOYSA-N.