Risedronate (sodium salt)

Risedronate is a heterocyclic orally active aminobisphosphonate. Like other bisphosphonates, it inhibits bone resorption. In addition, it has antimalarial activity and inhibits growth of P. falciparum in vitro (IC50 = 20.3 µM) and P. berghei in vivo (25 mg/kg for one week). It also inhibits protein prenylation by preventing the transfer of a farnesyl pyrophosphate group to parasite proteins. Formulations containing risedronate have been used to reduce fracture risk in both age- and steroid-related osteoporosis.Formal Name: P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid, monosodium salt. CAS Number: 115436-72-1. Molecular Formula: C7H10NO7P2 . Na. Formula Weight: 305.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 262 nm. SMILES: OC(P(O)(O)=O)(P(O)([O-])=O)CC1=CC=CN=C1.[Na+]. InChi Code: InChI=1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6,/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15),/q,+1/p-1. InChi Key: DRFDPXKCEWYIAW-UHFFFAOYSA-M.