Ricinine

Ricinine is a piperidine alkaloid that has been found in R. communis and has diverse biological activities. It is an inhibitor of acetylcholinesterase (AChE, IC50 = 54.5 µg/ml). It scavenges ABTS (Cay-27317) radicals and chelates iron (IC50s = 102.65 and 104.32 µg/ml, respectively). Ricinine is toxic to adult A. gambiae when used at a concentration of 0.04 mg/ml in a feeding assay. It is also toxic to mice with an intraperitoneal LD50 value of 340 mg/kg but an oral LD50 value of 3,000 mg/kg. It has been used as a biomarker of ricin poisoning.Formal Name: 1,2-dihydro-4-methoxy-1-methyl-2-oxo-3-pyridinecarbonitrile. CAS Number: 524-40-3. Synonyms: NSC 409913, NSC 642604. Molecular Formula: C8H8N2O2. Formula Weight: 164.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. lambdamax: 219, 316 nm. SMILES: N#CC1=C(C=CN(C)C1=O)OC. InChi Code: InChI=1S/C8H8N2O2/c1-10-4-3-7(12-2)6(5-9)8(10)11/h3-4H,1-2H3. InChi Key: PETSAYFQSGAEQY-UHFFFAOYSA-N. Origin: Synthetic.