Rhamnetin

Rhamnetin is a flavonoid that has been found in O. falcate and has diverse biological activities. It reduces production of reactive oxygen species (ROS) and apoptosis induced by miconazole (Cay-15420) in H9c2 cardiomyocytes. Rhamnetin inhibits LPS-induced TNF-alpha and nitric oxide (NO) production in rat neonatal organotypic hippocampal slice cultures (OHSCs) under control conditions and during ethanol withdrawal, as well as NMDA-induced neurotoxicity in OHSCs undergoing ethanol withdrawal. Dietary administration of rhamnetin (0.1 and 0.2% w/w) reduces serum levels of malondialdehyde (MDA) and liver and erythrocyte levels of thiobarbituric acid reactive substances (TBARS) in rats fed a cholesterol-free diet. Rhamnetin increases time spent in the target quadrant in the Morris water maze in a rat model of traumatic brain injury.Formal Name: 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-1-benzopyran-4-one. CAS Number: 90-19-7. Synonyms: CI-75690, 7-Methoxyquercetin, 7-Methylquercetin, NSC 19802, LY805921, beta-Rhamnocitrin. Molecular Formula: C16H12O7. Formula Weight: 316.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 255, 372 nm. SMILES: OC1=CC(OC)=CC2=C1C(C(O)=C(C3=CC=C(O)C(O)=C3)O2)=O. InChi Code: InChI=1S/C16H12O7/c1-22-8-5-11(19)13-12(6-8)23-16(15(21)14(13)20)7-2-3-9(17)10(18)4-7/h2-6,17-19,21H,1H3. InChi Key: JGUZGNYPMHHYRK-UHFFFAOYSA-N. Origin: Synthetic.