Retinyl Acetate

Retinyl acetate is a natural form of vitamin A (Cay-20241). It inhibits ascorbic acid- or ferrous sulfate-induced increases in malondialdehyde (MDA) levels in rat brain mitochondria when used at a concentration of 100 µM. Retinyl acetate binds to retinol-binding protein (Kd = 220 nM for the human protein) and inhibits organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3 in CHO cells expressing the human transporters (Kis = 1.22 and 3.89, respectively). It inhibits the formation of mammary adenocarcinomas induced by the polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene (DMBA, Cay-30383) in rats when administered at a dose of 2.5 mg/animal. Retinyl acetate (352 µmol/kg) is teratogenic to rat fetuses when administered to pregnant dams. Formulations containing retinyl acetate have been used as skin-conditioning agents in cosmetics.Formal Name: retinol acetate. CAS Number: 127-47-9. Synonyms: NSC 122045, NSC 122760, Ro 1-5275, Vitamin A Acetate. Molecular Formula: C22H32O2. Formula Weight: 328.5. Purity: >98%. Formulation: (Request formulation change), A semi-solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 16 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.3 mg/ml. lambdamax: 326 nm. SMILES: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1. InChi Code: InChI=1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+. InChi Key: QGNJRVVDBSJHIZ-QHLGVNSISA-N.