Remisporine B

Remisporine B is a polyketide and derivative of remisporine A that has been found in Penicillium and has immunosuppressant activity. It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 µg/ml, respectively).Formal Name: (5bS,7S,7aR,7bR,14bS)-7,7a,7b,8,14,14b-hexahydro-4,7,13-trihydroxy-2,11-dimethyl-5,14-dioxo-furo[2',3',4':3,4]indeno[1,2-b:6,7-b']bis[1]benzopyran-5b,7(5H)-dicarboxylic acid, dimethyl ester. CAS Number: 571194-06-4. Molecular Formula: C30H24O12. Formula Weight: 576.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: COC([C@]12[C@]3([H])[C@](C4=C(OC5=CC(C)=CC(O)=C5C4=O)C[C@@]3([H])[C@](O)(O2)C(OC)=O)([H])C6=C1C(C7=C(O)C=C(C)C=C7O6)=O)=O. InChi Code: InChI=1S/C30H24O12/c1-10-5-13(31)18-15(7-10)40-17-9-12-22-21(20(17)24(18)33)26-23(25(34)19-14(32)6-11(2)8-16(19)41-26)29(22,27(35)38-3)42-30(12,37)28(36)39-4/h5-8,12,21-22,31-32,37H,9H2,1-4H3/t12-,21-,22+,29+,30+/m1/s1. InChi Key: RRGJMIUFDPLICY-JJEZGDBSSA-N. Origin: Fungus/Remispora maritima.