Ravidasvir (hydrochloride)

Ravidasvir is an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A). It inhibits HCV replication in Huh7 replicon cells containing NS5A from the HCV genotypes 1a, -1b, and 3a with EC50 values of 0.12, 0.01, and 1.14 nM, respectively.Formal Name: N-[(1S)-1-[[(2S)-2-[5-[6-[2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-pyrrolidinyl]-1H-benzimidazol-6-yl]-2-naphthalenyl]-1H-imidazol-2-yl]-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-carbamic acid, methyl ester, dihydrochloride. CAS Number: 1303533-81-4. Synonyms: PPI-668. Molecular Formula: C42H50N8O6 . 2HCl. Formula Weight: 835.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 267, 321 nm. SMILES: O=C(N1[C@@H](CCC1)C2=NC3=CC=C(C4=CC(C=CC(C5=CN=C([C@H](CCC6)N6C([C@H](C(C)C)NC(OC)=O)=O)N5)=C7)=C7C=C4)C=C3N2)[C@H](C(C)C)NC(OC)=O.Cl.Cl. InChi Code: InChI=1S/C42H50N8O6.2ClH/c1-23(2)35(47-41(53)55-5)39(51)49-17-7-9-33(49)37-43-22-32(46-37)29-14-13-25-19-26(11-12-27(25)20-29)28-15-16-30-31(21-28)45-38(44-30)34-10-8-18-50(34)40(52)36(24(3)4)48-42(54)56-6,,/h11-16,19-24,33-36H,7-10,17-18H2,1-6H3,(H,43,46)(H,44,45)(H,47,53)(H,48,54),2*1H/t33-,34-,35-,36-,,/m0../s1. InChi Key: JYLMWUZJMRNMDA-SPRBZRACSA-N.