Ranitidine S-oxide

Ranitidine S-oxide is a metabolite of the histamine H2 receptor antagonist ranitidine (Cay-16939). It is formed via S-oxidation of ranitidine by flavin-containing monooxygenase 3 (FMO3) and FMO5. Ranitidine S-oxide is acutely cytotoxic to the aquatic species B. calyciflorus and C. dubia (LC50s = 4.51 and 7.85 mg/L, respectively), and it inhibits the reproduction of B. calyciflorus and C. dubia with chronic exposure (EC50s = 0.83 and 0.51 mg/L, respectively). It is mutagenic to S. typhimurium and genotoxic to E. coli when used at concentrations ranging from 0.312 to 0.625 µg/ml and 0.312 to 5 µg/ml, respectively.Formal Name: N'-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]sulfinyl]ethyl]-N-methyl-2-nitro-1,1-ethenediamine. CAS Number: 73851-70-4. Molecular Formula: C13H22N4O4S. Formula Weight: 330.4. Purity: >90%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 235, 327 nm. SMILES: O=S(CC1=CC=C(CN(C)C)O1)CCN/C(NC)=C/[N+]([O-])=O. InChi Code: InChI=1S/C13H22N4O4S/c1-14-13(9-17(18)19)15-6-7-22(20)10-12-5-4-11(21-12)8-16(2)3/h4-5,9,14-15H,6-8,10H2,1-3H3/b13-9+. InChi Key: SKHXRNHSZTXSLP-UKTHLTGXSA-N.