rac-Tolterodine-d14 (tartrate)

rac-Tolterodine-d14 is intended for use as an internal standard for the quantification of tolterodine (Cay-15027) by GC- or LC-MS. Tolterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 1.4, 2.7, 3.6, 3.1, and 2.2 nM for M1-5 receptors, respectively). It reduces intracellular calcium mobilization induced by carbachol (carbamoylcholine, Cay-14486) in bladder smooth muscle cells and submandibular gland cells isolated from cynomolgus monkeys (Kis = 3.16 and 2 nM, respectively). Tolterodine inhibits volume-induced bladder contractions and oxotremorine-induced salivation in rats (ID50s = 0.025 and 0.12 mg/kg, respectively). Formulations containing tolterodine have been used in the treatment of overactive bladder.Formal Name: 2-[3-[bis[1-(methyl-d3)ethyl-1,2,2,2-d4]amino]-1-phenylpropyl]-4-methyl-phenol, 2,3-dihydroxybutanedioate. Synonyms: PNU 200583E-d14. Molecular Formula: C22H17D14NO . C4H6O6. Formula Weight: 489.7. Purity: >99% deuterated forms (d1-d14). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: [2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])N(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])CCC(C1=CC=CC=C1)C2=C(C=CC(C)=C2)O.OC(C(C(O)=O)O)C(O)=O. InChi Code: InChI=1S/C22H31NO.C4H6O6/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24,5-1(3(7)8)2(6)4(9)10/h6-12,15-17,20,24H,13-14H2,1-5H3,1-2,5-6H,(H,7,8)(H,9,10)/i1D3,2D3,3D3,4D3,16D,17D,. InChi Key: TWHNMSJGYKMTRB-HHJIGIPXSA-N.