(R)-Bromoenol lactone

Description: The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase gamma (iPLA2gamma). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2beta except at high doses of 20-30 µM. (R)-BEL inhibits human recombinant iPLA2gamma with an IC50 of approximately 0.6 µM. Target: Others. Smiles: O=C1[C@@H](C=2C3=C(C=CC2)C=CC=C3)CC/C(=C\Br)/O1