(R)-BAY-598

(R)-BAY-598 is an inhibitor of the lysine N-methyltransferase SMYD2 (IC50 = 1.7 µM) and a less active enantiomer of (S)-BAY-598 (Cay-18238). It is selective for SMYD2 over proteinase-activated receptor 1 (PAR1, IC50 = >30 µM).Formal Name: N-[(4R)-1-[(cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl]-N-ethyl-2-hydroxy-acetamide. CAS Number: 1906920-28-2. Molecular Formula: C22H20Cl2F2N6O3. Formula Weight: 525.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: ClC1=C(Cl)C=CC(C2=NN(/C(NC3=CC=CC(OC(F)F)=C3)=N\C#N)C[C@H]2N(C(CO)=O)CC)=C1. InChi Code: InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13)22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H,28,29)/t18-/m1/s1. InChi Key: OTTJIRVZJJGFTK-GOSISDBHSA-N.