Quin-2 AM

Quin-2 AM is a cell-permeant acetoxymethyl ester of the high affinity fluorescent calcium indicator quin-2 (Cay-20421). As quin-2 AM enters cells, it is hydrolyzed by intracellular esterases to produce quin-2. Quin-2 binds calcium with a Kd value of 115 nM. It displays high selectivity for calcium, as it is not affected by sodium gradients, membrane potential, or intracellular pH. High affinity probes like quin-2 are ideal for monitoring low levels of calcium, as are found in resting cells. Loadings of up to 2 mM quin-2 are without serious toxic effects, so quin-2 may be used to buffer intracellular calcium transients. Excitation and emission maxima for quin-2 are 339 and 492 nm, respectively.Formal Name: N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-N-[2-[[8-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-6-methoxy-2-quinolinyl]methoxy]-4-methylphenyl]-glycine(acetyloxy)methyl ester. CAS Number: 83104-85-2. Synonyms: Quin-2 Acetoxymethyl ester. Molecular Formula: C38H43N3O18. Formula Weight: 829.8. Purity: >90%. Emission: 492 nm. Excitation: 339 nm. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C(OCOC(C)=O)CN(CC(OCOC(C)=O)=O)C1=C2C(C=CC(COC3=C(N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)C=CC(C)=C3)=N2)=CC(OC)=C1. InChi Code: InChI=1S/C38H43N3O18/c1-23-7-10-31(40(14-34(46)56-19-52-24(2)42)15-35(47)57-20-53-25(3)43)33(11-23)51-18-29-9-8-28-12-30(50-6)13-32(38(28)39-29)41(16-36(48)58-21-54-26(4)44)17-37(49)59-22-55-27(5)45/h7-13H,14-22H2,1-6H3. InChi Key: ANRZUBSJAOAXHS-UHFFFAOYSA-N.