Quazinone

Description: Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties. It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 µM), increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner (10-300 µg/kg), decreases systolic and diastolic blood pressure, and inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner. Target: Others. Smiles: C[C@H]1N2C(NC=3C(C2)=C(Cl)C=CC3)=NC1=O. References: Taher, A., Meyer, M., Stief, C.G., et al. Cyclic nucleotide phosphodiesterase in human cavernous smooth muscle. World J. Urol. 15(1), 32-35 (1997).