QLT0267

QLT0267 is an inhibitor of integrin-linked kinase (ILK, IC50 = 26 nM). It is greater than 10-fold selective for ILK over cyclin-dependent kinase 1 (Cdk1), Cdk2, and Cdk5, as well as greater than 1,000-fold selective for ILK over C-terminal Src kinase (CSK), DNA-PK, Pim-1, Akt, PKC, and casein kinase 2 (CK2), at 10 mg/ml. QLT0267 inhibits the growth of NPA187 papillary thyroid cancer cells (IC50 = ~3 µM) and induces apoptosis in NPA187, DRO, and K4 cancer cell lines. In vivo, QLT0267 (100 mg/kg) reduces tumor growth in a DRO mouse xenograft model. It also reduces tumor volume and intratumoral blood vessel mass in a U87MG glioblastoma mouse xenograft model.Formal Name: 4-((4-methoxyphenyl)diazenyl)-1H-pyrazole-3,5-diamine. CAS Number: 866409-68-9. Molecular Formula: C10H12N6O. Formula Weight: 232.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: slightly soluble. lambdamax: 230, 365 nm. SMILES: COC1=CC=C(N=NC2=C(N)NN=C2N)C=C1. InChi Code: InChI=1S/C10H12N6O/c1-17-7-4-2-6(3-5-7)13-14-8-9(11)15-16-10(8)12/h2-5H,1H3,(H5,11,12,15,16). InChi Key: QNRNTYHAOBVOKW-UHFFFAOYSA-N.