Pyronaridine (phosphate)

Pyronaridine is an antimalarial agent. It is active against six P. falciparum drug-sensitive or -resistant strains (IC50s = 1.53-3.94 nM). Pyronaridine (3, 6, and 8 mg/kg) in combination with artesunate (Cay-11817) reduces parasitemia in P. chabaudi-infected mice. It inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infected A459 cells overexpressing angiotensin-converting enzyme 2 (ACE2, IC50 = 198 nM). Pyronaridine is also cytotoxic against a panel of human cancer cells lines, including breast, ovarian, and lung cancer cells, with 50% cytotoxic concentration values (CC50s) ranging from 1.6 to 9.4 µM. Formulations containing pyronaridine have been used in the treatment of malaria.Formal Name: 4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-phenol, tetraphosphate. CAS Number: 76748-86-2. Synonyms: PND. Molecular Formula: C29H32ClN5O2 . 4H3PO4. Formula Weight: 910.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. lambdamax: 239, 278, 359, 425 nm. SMILES: ClC1=CC=C2C(N=C(C=CC(OC)=N3)C3=C2NC4=CC(CN5CCCC5)=C(O)C(CN6CCCC6)=C4)=C1.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O. InChi Code: InChI=1S/C29H32ClN5O2.4H3O4P/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35,4*1-5(2,3)4/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32),4*(H3,1,2,3,4). InChi Key: YKUQEKXHQFYULM-UHFFFAOYSA-N.