Pyridoxatin

Pyridoxatin is a fungal metabolite originally isolated from Acremonium with diverse biological activities. It inhibits production of thiobarbituric acid reactive substance (TBARS) in vitro (IC50 = 0.55 µg/ml). Pyridoxatin inhibits hemolysis induced by the free radical generator AAPH in rat erythrocytes (IC50 = 1.95 µg/ml). It is active against C. albicans (MIC = 1.64 µg/ml). Pyridoxatin is cytotoxic in a panel of 21 cancer cell lines (EC50s = 0.10-7.04 µg/ml). It also inhibits gelatinase A (IC50 = 15.2 µM).Formal Name: 3-[(1R,2S,4R,6S)-2-ethenyl-4,6-dimethylcyclohexyl]-1,4-dihydroxy-2(1H)-pyridinone. CAS Number: 135529-30-5. Molecular Formula: C15H21NO3. Formula Weight: 263.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: C[C@H]1C[C@@H](C=C)[C@H](C2=C(O)C=CN(O)C2=O)[C@@H](C)C1. InChi Code: InChI=1S/C15H21NO3/c1-4-11-8-9(2)7-10(3)13(11)14-12(17)5-6-16(19)15(14)18/h4-6,9-11,13,17,19H,1,7-8H2,2-3H3/t9-,10+,11-,13-/m1/s1. InChi Key: OQJADHLOEAOIGC-LSCVPOLPSA-N. Origin: Fungus/Albophoma yamanashiensis.