PXS-5505 (hydrochloride)

PXS-5505 is a pan inhibitor of lysyl oxidase (LOX) and LOX-like oxidases (LOXL, IC50s = 0.493, 0.159, 0.57, 0.18, and 0.19 µM for fibroblast LOX and recombinant human LOXL1-4, respectively). It is selective for LOX and LOXL1-4 over other recombinant human oxidases, including diamine oxidase (DAO), vascular adhesion protein-1 (VAP-1), monoamine oxidase A (MAO-A), and MAO-B (IC50s = >30 µM for all). PXS-5505 (15 mg/kg) reduces bleomycin-induced increases in dermal thickness and the levels of alpha-smooth muscle actin in a mouse model of systemic sclerosis. It reduces fibrosis in rodent models of bleomycin-induced pulmonary fibrosis, cardiac ischemia-reperfusion injury, renal unilateral ureteral obstruction, and carbon tetrachloride-induced liver fibrosis. It also reduces collagen crosslinking in KPC cancer-associated fibroblast (CAF) 3D organotypic matrices. PXS-5505 (20 mg/kg) increases survival to a greater extent than gemcitabine alone when administered in combination with the anticancer nucleoside derivative gemcitabine (Cay-11690, Cay-9003096), reduces gemcitabine-induced increases in collagen levels and stiffness, and reduces liver metastatic burden in autochthonous KPC pancreatic ductal adenocarcinoma mouse models.Formal Name: (2Z)-3-fluoro-4-(8-quinolinylsulfonyl)-2-buten-1-amine, dihydrochloride. CAS Number: 2409964-23-2. Molecular Formula: C13H13FN2O2S . 2HCl. Formula Weight: 353.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Slightly Soluble: 0.1-1 mg/ml, PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: F/C(CS(=O)(C1=CC=CC2=C1N=CC=C2)=O)=C\CN.Cl.Cl. InChi Code: InChI=1S/C13H13FN2O2S.2ClH/c14-11(6-7-15)9-19(17,18)12-5-1-3-10-4-2-8-16-13(10)12,,/h1-6,8H,7,9,15H2,2*1H/b11-6-,,. InChi Key: YYYHSAUHJBNINZ-LEOXJOGCSA-N.