Prulifloxacin

Prulifloxacin is a prodrug form of the fluoroquinolone antibiotic ulifloxacin. In vivo, prulifloxacin increases survival in mouse models of systemic S. aureus, S. pyogenes, S. pneumoniae, E. coli, K. pneumoniae, S. marcescens, or P. aeruginosa infection (ED50s = 0.35-23 mg/kg). It also increases survival in a mouse model of K. pneumoniae-induced respiratory tract infection (ED50 = 0.981 mg/kg).Formal Name: 6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo-1H,4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid. CAS Number: 123447-62-1. Synonyms: NM441. Molecular Formula: C21H20FN3O6S. Formula Weight: 461.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml. SMILES: FC1=C(C=C2C(C(C(C(O)=O)=C3SC(C)N32)=O)=C1)N(CC4)CCN4CC(O5)=C(C)OC5=O. InChi Code: InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28). InChi Key: PWNMXPDKBYZCOO-UHFFFAOYSA-N.