Prostaglandin D Synthase (hematopoietic-type) Inhibitor I

Prostaglandin D synthase (hematopoietic-type) (H-PGDS) inhibitor I is an inhibitor of H-PGDS (IC50 = 32 nM for the human enzyme). It is selective for H-PGDS over lipocalin-type PGDS, microsomal prostaglandin E synthase-1 (mPGES-1), COX-1, COX-2, and 5-lipoxygenase (5-LO, IC50s = >10,000 nM for all). H-PGDS inhibitor I (1 or 10 mg/kg) inhibits PGD2 (Cay-12010) production in vivo in rat spleen. It completely inhibits allergen-induced airway hyperresponsiveness in an ovine model of asthma.Formal Name: 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide. CAS Number: 1033836-12-2. Synonyms: H-PGDS Inhibitor I. Molecular Formula: C19H19F4N3O. Formula Weight: 381.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 260, 287 nm. SMILES: O=C(C1=CC=C(C2=CC=CC(F)=C2)N=C1)NC3CCN(CC(F)(F)F)CC3. InChi Code: InChI=1S/C19H19F4N3O/c20-15-3-1-2-13(10-15)17-5-4-14(11-24-17)18(27)25-16-6-8-26(9-7-16)12-19(21,22)23/h1-5,10-11,16H,6-9,12H2,(H,25,27). InChi Key: LPUCBGGXXIUBAZ-UHFFFAOYSA-N.