Propiverine (hydrochloride)

Propiverine is an antagonist of muscarinic acetylcholine receptors (mAChRs). It binds to M1 and M2 mAChRs in rat bladder and submaxillary gland, respectively (Kis = 0.3 and 0.19 µM, respectively), and inhibits carbachol-induced contraction of bladder strips isolated from patients with normal bladder activity and detrusor overactivity associated with benign prostatic hyperplasia (pA2s = 7.7 and 7.6, respectively). Formulations containing propiverine have been used in the treatment of overactive bladder.Formal Name: alpha-phenyl-alpha-propoxy-benzeneacetic acid, 1-methyl-4-piperidinyl ester, monohydrochloride. CAS Number: 54556-98-8. Molecular Formula: C23H29NO3 . HCl. Formula Weight: 403.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: Slightly soluble, Ethanol: Slightly soluble. SMILES: O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)OCCC)OC3CCN(CC3)C.Cl. InChi Code: InChI=1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21,/h4-13,21H,3,14-18H2,1-2H3,1H. InChi Key: KFUJMHHNLGCTIJ-UHFFFAOYSA-N.