Procyanidin B1

Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin (Cay-70940) and (-)-epicatechin (Cay-11807). It inhibits hepatitis C virus RNA replication (EC50 = 72 µM), while (+)-catechin and (-)-epicatechin do not, up to concentrations of 200 µM. Procyanidin B1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells. It decreases TNF-alpha, phosphorylated p38 MAPK, and NF-kappaB levels following LPS administration.Formal Name: (2R,2'R,3R,3'S,4R)-2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-[4,8'-bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol. CAS Number: 20315-25-7. Synonyms: (-)-Epicatechin-(4beta-8)-(+)-catechin, Proanthocyanidin B1, Procyanidol B1. Molecular Formula: C30H26O12. Formula Weight: 578.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 280 nm. SMILES: OC1=CC=C([C@H]2OC(C=C(O)C=C3O)=C3[C@H](C4=C(O)C=C(O)C5=C4O[C@H](C6=CC=C(O)C(O)=C6)[C@@H](O)C5)[C@H]2O)C=C1O. InChi Code: InChI=1S/C30H26O12/c31-13-7-20(37)24-23(8-13)41-29(12-2-4-16(33)19(36)6-12)27(40)26(24)25-21(38)10-17(34)14-9-22(39)28(42-30(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,22,26-29,31-40H,9H2/t22-,26+,27+,28+,29+/m0/s1. InChi Key: XFZJEEAOWLFHDH-UKWJTHFESA-N. Origin: Plant/Grape seeds.