Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Procyanidin A1 is a polyphenol flavonoid dimer of (-)-epicatechin (Cay-11807) and (+)-catechin... more
Product information "Procyanidin A1"
Procyanidin A1 is a polyphenol flavonoid dimer of (-)-epicatechin (Cay-11807) and (+)-catechin (Cay-70940) that has been found in R. spiciferum and has diverse biological activities. It binds to placenta growth factor (PlGF) and VEGF (Kds = 394 and 476 nM, respectively) and increases the activity of JAK2 (EC50 = 660 nM). Procyanidin A1 scavenges superoxide radicals (IC50 = 14.7 µM) and inhibits the cytopathic effects of HIV-1 in MT-4 cells (IC50 = 14 µg/ml). It increases the proliferation of isolated mouse splenocytes and peritoneal macrophages when used at concentrations ranging from 25 to 100 µM and DAMI megakaryoblasts (EC50 = 8.58 µM). Procyanidin A1 (50 mg/kg) prevents decreases in the number of platelets in peripheral blood and megakaryocytes in the bone marrow in a mouse model of thrombocytopenia induced by the DNA cross-linking agent carboplatin (Cay-13112).Formal Name: (2R,3S,8S,14R,15R)-2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-8,14-methano-2H,14H-1-benzopyrano[7,8-d][1,3]benzodioxocin-3,5,11,13,15-pentol. CAS Number: 103883-03-0. Synonyms: Epicatechin-(4beta->8,2beta->O->7)-catechin, Proanthocyanidin A1, Procyanidol A1. Molecular Formula: C30H24O12. Formula Weight: 576.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: OC1=C(C[C@H](O)[C@@H](C2=CC(O)=C(O)C=C2)O3)C3=C([C@@]([C@H]4O)([H])C(C(O)=CC(O)=C5)=C5O[C@@]4(C6=CC(O)=C(O)C=C6)O7)C7=C1. InChi Code: InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8,10,21,26-27,29,31-39H,9H2/t21-,26+,27+,29+,30-/m0/s1. InChi Key: NSEWTSAADLNHNH-TXZJYACMSA-N. Origin: Plant/Grape seeds.
Keywords: | Epicatechin-(4beta->8,2beta->O->7)-catechin, Proanthocyanidin A1, Procyanidol A1, (2R,3S,8S,14R,15R)-2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-8,14-methano-2H,14H-1-benzopyrano[7,8-d][1,3]benzodioxocin-3,5,11,13,15-pentol |
Supplier: | Cayman Chemical |
Supplier-Nr: | 38893 |
Properties
Application: | Bioactive polyphenol flavonoid dimer |
MW: | 576.5 D |
Formula: | C30H24O12 |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 103883-03-0| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed