Procarbazine hydrochloride

Description: Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Target: DNA/RNA Synthesis, DNA Alkylator/Crosslinker. Smiles: c1(C(=O)NC(C)C)ccc(cc1)CNNC.Cl. References: Ogawa K, et al. Mutat Res,2003, 539(1-2), 145-155.