PRL-3 Inhibitor

Phosphatase of regenerating liver 3 (PRL-3, also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.Formal Name: 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone. CAS Number: 893449-38-2. Synonyms: BR-1, P0108, Phosphatase of Regenerating Liver 3 Inhibitor, PTP4A3 Inhibitor. Molecular Formula: C17H11Br2NO2S2. Formula Weight: 485.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 16 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 273, 384 nm. SMILES: BrC1=CC=C(OCC2=C(Br)C=CC=C2)C(/C=C3C(NC(S\3)=S)=O)=C1. InChi Code: InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+. InChi Key: HXNBAOLVPAWYLT-OVCLIPMQSA-N.