Pravastatin-d3 (sodium salt)

Pravastatin-d3 is intended for use as an internal standard for the quantification of pravastatin (Cay-10010343) by GC- or LC-MS. Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Cay-10010340). In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per day for five weeks. Formulations containing pravastatin have been used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.Formal Name: (3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-(((S)-2-(methyl-d3)butanoyl)oxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoate, monosodium salt. CAS Number: 1329836-90-9. Molecular Formula: C23H32D3O7 . Na. Formula Weight: 449.5. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly soluble, Water: Slightly soluble. SMILES: O=C(O[C@H]1C[C@H](O)C=C2[C@@]1([H])[C@@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@@H](C)C=C2)[C@@H](C([2H])([2H])[2H])CC.[Na+]. InChi Code: InChI=1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28,/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28),/q,+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-,/m0./s1/i2D3,. InChi Key: VWBQYTRBTXKKOG-ZJDKIXRVSA-M.