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You can also order by e-mail: info@biomol.com
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P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large... more
Product information "PPADS (sodium salt)"
P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 µM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.Formal Name: 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic acid, tetrasodium salt. CAS Number: 192575-19-2. Synonyms: Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid. Molecular Formula: C14H10N3O12PS2 . 4Na. Formula Weight: 599.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Water: Slightly soluble. lambdamax: 363, 482 nm. SMILES: [H]C(C1=C(COP([O-])([O-])=O)C(/N=N/C2=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C=C2)=NC(C)=C1O)=O.[Na+].[Na+].[Na+].[Na+]. InChi Code: InChI=1S/C14H14N3O12PS2.4Na/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28,,,,/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28),,,,/q,4*+1/p-4/b17-16+,,,,. InChi Key: KURWUCJJNVPCHT-PGXCWKBOSA-J.
Keywords: | Pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid, 4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic acid, tetrasodium salt |
Supplier: | Cayman Chemical |
Supplier-Nr: | 14537 |
Properties
Application: | P2 purinergic receptor antagonist |
MW: | 599.3 D |
Formula: | C14H10N3O12PS2 . 4Na |
Purity: | >95% |
Format: | Solid |
Database Information
CAS : | 192575-19-2| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
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H Phrases: | H315, H319, H335 |
P Phrases: | P261, P264, P271, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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