Ponatinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50... more
Product information "Ponatinib"
Description: Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50 values of 0.37 nM (Abl), 1.1 nM (PDGFRalpha), 1.5 nM (VEGFR2), 2.2 nM (FGFR1), and 5.4 nM (Src). Target: PDGFR, Bcr-Abl, Autophagy, Src, VEGFR, c-Kit, FGFR. Smiles: C(#CC1=CC(C(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)=CC=C1C)C=4N5C(=NC4)C=CC=N5. References: O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6,16(5):401-12.
| Keywords: | AP24534 |
| Supplier: | TargetMol |
| Supplier-Nr: | T2372 |
Properties
| MW: | 532.56 D |
| Formula: | C29H27F3N6O |
Database Information
Handling & Safety
| Storage: | +4°C |
| Shipping: | +20°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H311, H331 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P311, P312, P321, P330, P361+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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