Pleconaril

Pleconaril is an antipicornaviral agent.{52019, 52020} It inhibits Picornaviridae viral replication by binding to a hydrophobic pocket in the major VP1 capsid protein, which prevents uncoating of the viral RNA genome. Pleconaril inhibits replication of the rhinoviruses HRV-A2 and HRV-B14 in HeLa Rh cells (EC50s = 0.1 and 0.3 µM, respectively) and is not cytotoxic to HeLa Rh cells with a 50% cytotoxic concentration (CC50) of greater than 131 µM. It also inhibits replication of enterovirus 71 (EV71) in human rhabdomyosarcoma (RD) cells (EC50 = 15 µM) and is not cytotoxic to RD cells (CC50 = >131 µM). Pleconaril (80 mg/kg per day) increases survival of EV71-infected mouse pups from 20 to 80%.Formal Name: 3-[3,5-dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole. CAS Number: 153168-05-9. Synonyms: VP 63843, Win 63843. Molecular Formula: C18H18F3N3O3. Formula Weight: 381.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 262 nm. SMILES: CC1=C(OCCCC2=CC(C)=NO2)C(C)=CC(C3=NOC(C(F)(F)F)=N3)=C1. InChi Code: InChI=1S/C18H18F3N3O3/c1-10-7-13(16-22-17(27-24-16)18(19,20)21)8-11(2)15(10)25-6-4-5-14-9-12(3)23-26-14/h7-9H,4-6H2,1-3H3. InChi Key: KQOXLKOJHVFTRN-UHFFFAOYSA-N.