PKR-IN-C16
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to... more
Product information "PKR-IN-C16"
Description: PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. Target: Others. Smiles: O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1. References: Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1beta production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan,64:73-83.
| Supplier: | TargetMol |
| Supplier-Nr: | T16550 |
Properties
| Application: | EIF2AK2 inhibitor |
| MW: | 268.29 D |
| Formula: | C13H8N4OS |
Database Information
| CAS : | 608512-97-6| Matching products |
| KEGG ID : | K16195 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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