Piperazine Erastin

Piperazine erastin is an inducer of ferroptosis. It inhibits glutamate release in human CCF-STTG1 astrocytoma cells (IC50 = 0.8 µM), indicating inhibition of the system xc- cystine/glutamate transporter, and decreases glutathione (GSH) levels in HT-1080 fibrosarcoma cells when used at a concentration of 10 µM. Piperazine erastin inhibits the growth of BJeLR cells overexpressing the H-Ras activating mutation H-RasG12V (IC50 = 0.3 µM). It increases hepatic mRNA expression of the gene encoding Cox-2 and prevents tumor formation in an HT-1080 mouse xenograft model when administered at a dose of 60 mg/kg.Formal Name: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[2-(1-methylethoxy)-5-(1-piperazinylmethyl)phenyl]-4(3H)-quinazolinone. CAS Number: 1538593-71-3. Molecular Formula: C35H41ClN6O4. Formula Weight: 645.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: insol, DMSO: 10 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 227 nm. SMILES: O=C1C2=C(N=C(CN3CCN(CC3)C(COC4=CC=C(C=C4)Cl)=O)N1C5=CC(CN6CCNCC6)=CC=C5OC(C)C)C=CC=C2. InChi Code: InChI=1S/C35H41ClN6O4/c1-25(2)46-32-12-7-26(22-39-15-13-37-14-16-39)21-31(32)42-33(38-30-6-4-3-5-29(30)35(42)44)23-40-17-19-41(20-18-40)34(43)24-45-28-10-8-27(36)9-11-28/h3-12,21,25,37H,13-20,22-24H2,1-2H3. InChi Key: XGKULGPEBBYKCA-UHFFFAOYSA-N.