Pinoresinol Diglucoside

Pinoresinol diglucoside is a lignan that has been found in E. ulmoides and has diverse biological activities. It inhibits peroxidation of a linoleic acid emulsion by 64.2% when used at a concentration of 20 µg/ml, scavenges hydrogen peroxide and 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805), ABTS (Cay-27317), and superoxide anion free radicals, and has ferrous ion metal chelating activity in cell-free assays. In vivo, pinoresinol diglucoside (10, 20, and 40 mg/kg) inhibits increases in serum levels of inorganic phosphate, IL-6, and TNF-alpha and decreases in serum calcium levels and transverse diameter, weight, bone mineral content, and bone mineral density of the right femur in a rat model of osteoporosis induced by dexamethasone (Cay-11015).Formal Name: [(1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis(2-methoxy-4,1-phenylene) bis-beta-D-glucopyranoside. CAS Number: 63902-38-5. Synonyms: (+)-Pinoresinol di-O-beta-D-glucopyranoside. Molecular Formula: C32H42O16. Formula Weight: 682.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 10mg/mL, PBS (pH 7.2): 3mg/mL. lambdamax: 274 nm. SMILES: COC1=C(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=CC([C@@H]3[C@@]4([H])CO[C@H](C5=CC(OC)=C(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C=C5)[C@@]4([H])CO3)=C1. InChi Code: InChI=1S/C32H42O16/c1-41-19-7-13(3-5-17(19)45-31-27(39)25(37)23(35)21(9-33)47-31)29-15-11-44-30(16(15)12-43-29)14-4-6-18(20(8-14)42-2)46-32-28(40)26(38)24(36)22(10-34)48-32/h3-8,15-16,21-40H,9-12H2,1-2H3/t15-,16-,21+,22+,23+,24+,25-,26-,27+,28+,29+,30+,31+,32+/m0/s1. InChi Key: ZJSJQWDXAYNLNS-FUPWJLLWSA-N. Origin: Plant/Eucommia ulmoides Oliver.