Pimodivir HCl

Description: Pimodivir is an inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. The cell-based EC50 for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay. VX-787 is active against a diverse panel of influenza A virus strains. Target: Others. Smiles: FC1=CN=C2NC=C(C3=NC=C(F)C(N[C@@H]4[C@H](C5CCC4CC5)C(O)=O)=N3)C2=C1.FC6=CN=C7NC=C(C8=NC=C(F)C(N[C@@H]9[C@H](C%10CCC9CC%10)C(O)=O)=N8)C7=C6.Cl.O.Cl. References: Boyd MJ, Bandarage UK, Bennett H, Byrn RR, Davies I, Gu W, Jacobs M, Ledeboer MW, Ledford B, Leeman JR, Perola E, Wang T, Bennani Y, Clark MP, Charifson PS. Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors. Bioorg Med Chem Lett. 2015 May 1,25(9):1990-4. doi: 10.1016/j.bmcl.2015.03.013. Erratum in: Bioorg Med Chem Lett. 2016 Jan 1,26(1):240. PubMed PMID: 25827523.