Pimodivir

Pimodivir is an inhibitor of influenza virus polymerase basic protein 2 (PB2, KD = i = ~1.6 µM) and inhibits the activity of Axl and calcium/calmodulin-dependent protein kinase IIbeta (CaMKIIbeta) by greater than 50% in a panel of 65 human and rat kinases. Pimodivir decreases the replication of seven adamantine- and neuraminidase inhibitor-resistant strains of influenza virus A (EC50s = 16070), zanamivir (Cay-15123), and favipiravir (T-705, Cay-23384) with 50% combination index (CI50) values of 0.58, 0.64, and 0.89, respectively, in a cell-based assay. Pimodivir increases survival in a mouse model of intranasal influenza A infection when administered at doses of 1, 3, and 10 mg/kg twice per day.Formal Name: (2S,3S)-3-[[5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-4-pyrimidinyl]amino]-bicyclo[2.2.2]octane-2-carboxylic acid. CAS Number: 1629869-44-8. Synonyms: JNJ 63623872, JNJ 872, VX 787. Molecular Formula: C20H19F2N5O2. Formula Weight: 399.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 222, 263 nm. SMILES: FC1=CN=C2C(C(C3=NC=C(F)C(N[C@H]4C(CC5)CCC5[C@@H]4C(O)=O)=N3)=CN2)=C1. InChi Code: InChI=1S/C20H19F2N5O2/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20(28)29/h5-10,15-16H,1-4H2,(H,23,24)(H,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1. InChi Key: JGPXDNKSIXAZEQ-SBBZOCNPSA-N. Origin: Synthetic.