Phenytoin

Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin (Cay-23889). Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal slices (EC50s = 42.8 and 33.5 µM, respectively). It protects against seizures induced by maximal electroshock (MES) in mice (ED50 = 10 mg/kg). Formulations containing phenytoin have been used in the treatment of tonic-clonic seizures and status epilepticus.Formal Name: 5,5-diphenyl-2,4-imidazolidinedione. CAS Number: 57-41-0. Synonyms: 5,5-Diphenylhydantoin, NSC 8722. Molecular Formula: C15H12N2O2. Formula Weight: 252.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 15 mg/ml. SMILES: O=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)N3)NC3=O. InChi Code: InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19). InChi Key: CXOFVDLJLONNDW-UHFFFAOYSA-N.